Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy

Ultrasmall lanthanide oxide nanoparticles (LNPs) are a class of inorganic nanoparticles that have attracted significant attention in the field of biomedicine due to their unique properties. These nanoparticles are typically less than 10 nm in diameter and exhibit excellent optical, magnetic, and thermal properties. As a result, they have been extensively explored for a wide range of biomedical applications, including imaging, sensing, drug delivery, and therapy.

This article provides a comprehensive overview of ultrasmall LNPs, including their synthesis, properties, and applications in biomedical imaging and therapy. We will discuss the key factors that influence the properties of these nanoparticles and highlight their potential for advancing healthcare.

Ultrasmall LNPs can be synthesized using a variety of methods, including chemical precipitation, hydrothermal synthesis, and sol-gel processing. The choice of synthesis method depends on the desired size, shape, and composition of the nanoparticles.

Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy (Woodhead Publishing Series in Biomaterial)

by Gang Ho Lee

5 out of 5

Language	:	English
File size	:	161686 KB
Text-to-Speech	:	Enabled
Screen Reader	:	Supported
Enhanced typesetting	:	Enabled
Print length	:	1573 pages
Paperback	:	96 pages
Item Weight	:	10.6 ounces
Hardcover	:	208 pages
Dimensions	:	6.14 x 0.38 x 9.21 inches

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Chemical precipitation is a simple and straightforward method that involves the addition of a lanthanide salt to a solution of a base. This results in the formation of a precipitate that can be collected and washed to obtain the desired nanoparticles.

Hydrothermal synthesis is a hydrothermal method that involves the slow crystallization of lanthanide salts in a high-temperature, high-pressure environment. This method can be used to produce nanoparticles with a narrow size distribution and high crystallinity.

Sol-gel processing is a versatile method that involves the hydrolysis and condensation of a lanthanide precursor in a solvent. This method can be used to produce nanoparticles with a variety of shapes and compositions.

Ultrasmall LNPs exhibit a number of unique properties that make them suitable for biomedical applications. These properties include:

• High surface area: The high surface area of ultrasmall LNPs provides a large number of sites for the attachment of functional groups and biomolecules. This allows for the nanoparticles to be easily modified with targeting ligands, imaging agents, and therapeutic payloads.
• Excellent optical properties: Ultrasmall LNPs exhibit strong absorption and emission of light in the near-infrared (NIR) region. This makes them ideal for use in optical imaging applications, such as fluorescence imaging and photoacoustic imaging.
• High magnetic susceptibility: Ultrasmall LNPs exhibit a high magnetic susceptibility, which allows them to be manipulated using magnetic fields. This property can be used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI).
• Low toxicity: Ultrasmall LNPs are generally considered to be non-toxic. This makes them suitable for use in vivo applications, such as drug delivery and therapy.

Ultrasmall LNPs have been extensively explored for a variety of biomedical imaging applications. These applications include:

• Fluorescence imaging: Ultrasmall LNPs can be labeled with fluorescent dyes to enable them to be visualized using fluorescence microscopy. This technique can be used to track the nanoparticles in vivo and to visualize their distribution in tissues and organs.
• Photoacoustic imaging: Ultrasmall LNPs can be used as contrast agents for photoacoustic imaging. This technique uses sound waves to generate images of tissues and organs. The nanoparticles absorb light and convert it into sound waves, which can be detected by an ultrasound transducer.
• Magnetic resonance imaging (MRI): Ultrasmall LNPs can be used as contrast agents for MRI. The nanoparticles enhance the magnetic susceptibility of tissues and organs, which can be detected by an MRI scanner. This technique can be used to visualize the nanoparticles in vivo and to assess their distribution in tissues and organs.
• Magnetic particle imaging (MPI): Ultrasmall LNPs can be used as tracers for MPI. This technique uses magnetic fields to generate images of tissues and organs. The nanoparticles are magnetized and then injected into the body. The magnetic fields interact with the nanoparticles and generate signals that can be detected by an MPI scanner.

Ultrasmall LNPs have also been explored for a variety of biomedical therapy applications. These applications include:

• Drug delivery: Ultrasmall LNPs can be used to deliver drugs to specific cells or tissues in the body. The nanoparticles can be coated with targeting ligands that bind to receptors on the surface of the target cells. This allows the nanoparticles to deliver their payload directly to the desired site of action.
• Photothermal therapy: Ultrasmall LNPs can be used for photothermal therapy. This technique uses light to heat up the nanoparticles and kill cancer cells. The nanoparticles absorb light and convert it into heat, which can damage the surrounding cancer cells.
• Radiotherapy: Ultrasmall LNPs can be used for radiotherapy. This technique uses radiation to kill cancer cells. The nanoparticles can be coated with radioactive isotopes that emit radiation and kill cancer cells.

Ultrasmall LNPs are a promising class of nanoparticles with a wide range of biomedical applications. Their unique properties make them ideal for imaging, sensing, drug delivery, and therapy. As research into these nanoparticles continues, we can expect to see even more advances in the field of biomedicine.

Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy (Woodhead Publishing Series in Biomaterial)

by Gang Ho Lee

5 out of 5

Language	:	English
File size	:	161686 KB
Text-to-Speech	:	Enabled
Screen Reader	:	Supported
Enhanced typesetting	:	Enabled
Print length	:	1573 pages
Paperback	:	96 pages
Item Weight	:	10.6 ounces
Hardcover	:	208 pages
Dimensions	:	6.14 x 0.38 x 9.21 inches

FREE